Genetic counseling and testing can personalize your healthcare to help lower your risk of cancer.
The role of genetics in cancer is complex, and our understanding of it is advancing quickly. It is important to start by understanding these key points:
- No one inherits cancer, but some people may inherit the increased chance to develop cancer.
- Genes are instructions that help the body function properly. Certain genes called “cancer susceptibility genes” work to keep cancer from developing. Some people have an increased chance of developing cancer, because they have inherited changes (mutations) in these cancer susceptibility genes.
- If someone inherits a mutation in a cancer susceptibility gene, the risk of developing cancer over one’s lifetime is increased, but usually not by 100%.
At NECS, we provide genetic testing across a spectrum of inherited cancer syndromes, including:
- Hereditary breast and ovarian cancer
- Hereditary gastrointestinal cancer (colorectal, stomach, small bowel)
- Lynch syndrome
- Li-Fraumeni syndrome
- Familial pancreatic or prostate cancer
- Hereditary melanoma
Who has cancer?
One in three people will develop cancer at some point in their lifetime, but only 5–10% of cancers are hereditary. Most cancers are “sporadic,” caused by changes in a gene as a result of the environment (e.g., ultraviolet exposure), behavior (diet, tobacco or alcohol exposure), or by chance.
Signs of a hereditary cancer syndrome are:
- Early age of cancer diagnosis (before age 50);
- Multiple family members with the same or related cancers (e.g., breast and ovarian, or colon and uterine);
- Cancer in multiple generations;
- More than one cancer in a single individual; and
- A rare cancer (male breast cancer, adrenocortical carcinoma, sarcoma, hemangioblastoma, and others).
About genetic counseling
Our genetic counselors can help you and your family understand your chance of developing cancer due to a genetic condition known as a hereditary cancer syndrome. If you decide genetic counseling is right for you, a genetic counselor will meet with you to review:
- Personal and family medical histories;
- The genetic basis of cancer;
- The likelihood that the cancer in a family is due to an inherited change (also known as a mutation) in a cancer susceptibility gene;
- The risks for you and family members to develop cancer;
- The chance that genetic testing will be helpful, as well as its risks, limitations, and cost; and
- Personalized cancer screening, risk reduction, and prevention strategies.
Preparing for your first visit
Ask relatives for clear information about your family history of cancer, including type(s) of cancer, age(s) when it was found, and treatments received. Pathology and medical records are also helpful. You should be given a family history form to fill out. Or you can download the family history form here. Your initial visit takes about one hour. If you are a new patient to the practice you may meet with a doctor. You may also find it helpful to bring someone with you to your appointment.
Outcomes from the visit
Your genetic counselor may find that your risk of having a genetic susceptibility to cancer is low, and recommend against genetic testing.
If your family history does suggest a hereditary cancer syndrome, we will work together on a genetic testing plan for you and/or other family members.