Below is a list of current clinical trials open to enrollment at New England Cancer Specialists. Trials can open and close very quickly, depending on the phase of the study, responses from patients already enrolled, or FDA requests.

We try to have a trial available in every disease area, but this isn’t always possible. If you don’t see a study that might be right for you, please ask your doctor or nurse.

For a full list of clinical trials across the U.S., visit

NECS Providers - For more information on these clinical trials, visit (log-in required): NECS Clinical Trials



Bladder, T-6-16 (MK3475-361-00) A Phase III Randomized, Controlled Clinical Trial of Pembrolizumab with or without Platinum-Based Combination Chemotherapy versus Chemotherapy in Subjects with Advanced of Metastatic Urothelial Carcinoma.


Brain EV-2-16 (OT-15-001) STELLAR
A Phase III, Randomized, Open-Label Study to Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma that Progress/Recur after Irradiation and Adjuvant Temozolomide Chemotherapy.

Brain, A071102

A Phase II/III Randomized Trial of Veloparib or Placebo in Combination With Adjuvant Temozolomide in Newly Diagnosed Glioblastoma with MGMT Promoter Hypermethylation



Breast, AO11401 (BWEL)
Randomized Phase III Trial Evaluating The Role Of Weight Loss in Adjuvant Treatment Of Overweight And Obese Women With Early Breast Cancer

Breast, CB-1-15 (CP-MGAH22-04/SOPHIA)
A Phase III, Randomized Study of Margetuximab Plus Chemotherapy vs. Trastuzumab Plus Chemotherapy in Treatment in Patien
ts with HER2+ MBC Who Have Received Two Prior anti-Her2 Therapies and Require Systemic Treatment

Breast, CB-2-15, Alliance Foundation (AFT-05/PALLAS)
Breast, CB-2-15, Alliance Foundation (AFT-05/PALLAS): Palbociclib Collaborative Adjuvant Study: A Randomized Phase III Trial of Palbociclib With Standard Adjuvant Endocrine Therapy Versus Standard Adjuvant Endocrine Therapy Alone for Hormone Receptor Positive (HR+) / Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Early Breast Cancer

Breast, CB-1-16 (C31006-TRIO) An Open-Label Phase II Study of MLN0128 (A TORC1/2 Inhibitor) in Combination With Fulvestrant in Women With ER-Positive/HER2-Negative Advanced or Metastatic Breast Cancer That Has Progressed During of After Aromatase Inhibitor Therapy. MLN0128 in Combination with Fulvestrant in Women With Advanced or Metastatic Breast Cancer After Aromatase Inhibitor Therapy.

Breast, CB-2-16 (MK3475-355) A Randomized, Double-Blind, Phase III Study of Pembrolizumab (MK-3475) plus Chemotherapy vs Placebo plus Chemotherapy for Previously Untreated Locally Recurrent Inoperable or Metastatic Triple Negative Breast Cancer

Breast, CB-1-17 (MK3475-522) A Phase III, Randomized, Double-blind Study to Evaluate Pembrolizumab plus Chemotherapy vs Placebo plus Chemotherapy as Neoadjuvant Therapy and Pembrolizumab vs Placebo as Adjuvant Therapy for Triple Negative Breast Cancer (TNBC)

Breast, CB-2-17 (AFT-38/PATINA) A Randomized, Open Label, Phase III Trial to Evaluate the Efficacy and Safety of Palbociclib + Anti-HER2 Therapy + Endocrine Therapy vs. Anti-HER2 Therapy + Endocrine Therapy after Induction Treatment for Hormone Receptor Positive (HR+)/HER2-Positive Metastatic Breast Cancer

Breast, CB-3-17 (AFT-25/COMET) Comparison of Operative to Monitoring and Endocrine Therapy (COMET) Trial for Low Risk DCIS: A Phase II Prospective Trial

Breast, CB-2-18 (ODO-TE-B301) A Multinational, Multicenter, Randomized, Phase 3 Study of Tesetaxel plus a Reduced Dose of Capecitabine versus Capecitabine Alone in Patients with HER2 Negative, Hormone Receptor Positive, Locally Advanced or Metastatic Breast Cancer Previously Treated with a Taxane



Genomics, T-3-17 (JAX2)
A Study of Oncology Clinician And Patient Experiences With Clinical Genomics in Maine

Genomics, EAY131 (MATCH)
Molecular Analysis for Therapy Choice


Leukemia, R-1-16 (informCLL)
A disease registry for patients with Chronic Lymphocytic Leukemia


Lung, T-4-15 (GO29527/IMpower 010)
A Phase III, Open-Label, Multicenter, Randomized, Study Evaluating the Efficacy and Safety of Atezolizumab (Anti-PD-L1 Antibody) Compared with Best Supportive Care Following Adjuvant Cisplatin-Based Chemotherapy in PD-L1-Selected Patients with Completely Resected Stage IB-IIIA NSCLC

Lung, Alliance A081105
Randomized Double Blind Placebo Controlled Study of Erlotinib or Placebo in Patients with Completely Resected Epidermal Growth Factor Receptor (EGFR) Mutant Non-small Cell Lung Cancer (NSCLC)

Lung, Alliance A151216
Adjuvent Lung Cancer Enrichment Marker Identification and Sequencing

Lung, ECOG E4512
A Phase III Double-Blind Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib versus Placebo for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein

Lung, EA5142
Adjuvant Nivolumab in Resected Lung Cancers (ANVIL) - A Randomized Phase III Study of Nivolumab After Surgical Resection and Adjuvant Chemotherapy in Non-Small Cell Lung Cancers (part of ALCHEMIST study).

Lung, EV-1-17 (KEYNOTE-598)
A Phase 3, Randomized, Double-Blind Study of Pembrolizumab plus Ipilimumab vs Pembrolizumab plus Placebo in Previously Untreated, Stage IV, Metastatic Non-small Cell Lung Cancer Subjects Whose Tumors are PD-L1 Positive (TPS ≥ 50%)



Melanoma, EA6141
Randomized Phase II/III Study of (Nivolumab + Ipilimumab + Sargramostom) vs (Niolumab + Ipilimumab) in Patients with Unresectable Stage III or Stage IV Melanoma  (Temporarily Closed)

Multiple Myeloma

Multiple Myeloma, R-1-17 (C16021) A Phase 3, Randomised , Placebo-Controlled, Double-Blind Study of Oral Ixazomib Maintenance Therapy After Initial Therapy in Patients With Newly Diagnosed Multiple Myeloma Not Treated With Stem Cell Transplantation  


Pancreatic, DU-1-17 (AM0010-301, ARTIST 1) A Randomized Phase 3 Study of AM0010 in Combination with FOLFOX Compared with FOLFOX Alone as Second-line Therapy in Patients with Metastatic Pancreatic Cancer that has Progressed During or Following a First-Line Gemcitabine Containing Regime


Pancreatic, DU-2-17 (CanStem111p) A Phase III Study of BBI-608 plus nab-Paclitaxel with Gemcitabine in Adult Patients with Metastatic Pancreatic Adenocarcinoma


Prostate, T-6-17 (AFT-19)
A Study of Androgen Annihilation in High-Risk Biochemically Relapsed Prostate Cancer