Below is a list of current clinical trials open to enrollment at New England Cancer Specialists. Trials can open and close very quickly, depending on the phase of the study, responses from patients already enrolled, or FDA requests.
We try to have a trial available in every disease area, but this isn’t always possible. If you don’t see a study that might be right for you, please ask your doctor or nurse.
For a full list of clinical trials across the U.S., visit www.clinicaltrials.gov.
NECS Providers - For more information on these clinical trials, visit (log-in required): NECS Clinical Trials
Bladder, S1314 (SWOG)
A randomized Phase II Study of Co-Expression Extrapolation (Coxen) With Neoadjuvant Chemotherapy For Localized, Muscle-Invasive Bladder Cancer.
Bladder, T-6-16 (MK3475-361-00) A Phase III Randomized, Controlled Clinical Trial of Pembrolizumab with or without Platinum-Based Combination Chemotherapy versus Chemotherapy in Subjects with Advanced of Metastatic Urothelial Carcinoma.
Brain EV-2-16 (OT-15-001) STELLAR
A Phase III, Randomized, Open-Label Study to Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma that Progress/Recur after Irradiation and Adjuvant Temozolomide Chemotherapy.
Breast, AO11401 (BWEL)
Randomized Phase III Trial Evaluating The Role Of Weight Loss in Adjuvant Treatment Of Overweight And Obese Women With Early Breast Cancer
Breast, CB-1-15 (CP-MGAH22-04/SOPHIA)
A Phase III, Randomized Study of Margetuximab Plus Chemotherapy vs. Trastuzumab Plus Chemotherapy in Treatment in Patients with HER2+ MBC Who Have Received Two Prior anti-Her2 Therapies and Require Systemic Treatment
Breast, CB-2-15, Alliance Foundation (AFT-05/PALLAS)
Breast, CB-2-15, Alliance Foundation (AFT-05/PALLAS): Palbociclib Collaborative Adjuvant Study: A Randomized Phase III Trial of Palbociclib With Standard Adjuvant Endocrine Therapy Versus Standard Adjuvant Endocrine Therapy Alone for Hormone Receptor Positive (HR+) / Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Early Breast Cancer
Breast, CB-1-16 (C31006-TRIO) An Open-Label Phase II Study of MLN0128 (A TORC1/2 Inhibitor) in Combination With Fulvestrant in Women With ER-Positive/HER2-Negative Advanced or Metastatic Breast Cancer That Has Progressed During of After Aromatase Inhibitor Therapy. MLN0128 in Combination with Fulvestrant in Women With Advanced or Metastatic Breast Cancer After Aromatase Inhibitor Therapy.
Breast, CB-2-16 (MK3475-355) A Randomized, Double-Blind, Phase III Study of Pembrolizumab (MK-3475) plus Chemotherapy vs Placebo plus Chemotherapy for Previously Untreated Locally Recurrent Inoperable or Metastatic Triple Negative Breast Cancer
Breast, CB-1-17 (MK3475-522) A Phase III, Randomized, Double-blind Study to Evaluate Pembrolizumab plus Chemotherapy vs Placebo plus Chemotherapy as Neoadjuvant Therapy and Pembrolizumab vs Placebo as Adjuvant Therapy for Triple Negative Breast Cancer (TNBC)
Breast, CB-2-17 (AFT-38/PATINA) A Randomized, Open Label, Phase III Trial to Evaluate the Efficacy and Safety of Palbociclib + Anti-HER2 Therapy + Endocrine Therapy vs. Anti-HER2 Therapy + Endocrine Therapy after Induction Treatment for Hormone Receptor Positive (HR+)/HER2-Positive Metastatic Breast Cancer
Breast, CB-3-17 (AFT-25/COMET) Comparison of Operative to Monitoring and Endocrine Therapy (COMET) Trial for Low Risk DCIS: A Phase II Prospective Trial
Genomics, T-3-17 (JAX2)
A Study of Oncology Clinician And Patient Experiences With Clinical Genomics in Maine
Genomics, EAY131 (MATCH)
Molecular Analysis for Therapy Choice
Leukemia, R-1-16 (informCLL)
A disease registry for patients with Chronic Lymphocytic Leukemia
Lung, T-3-16 (CheckMate 370)
A Master Protocol of Phase 1/2 Studies of Nivolumab in Advanced NSCLC Using Nivolumab as Maintenance After Induction Chemotherapy or as First-line Treatment Alone or in Combination With Standard of Care Therapies (CheckMate 370: CHECKpoint Pathway and NivoluMAb Clinical Trial Evaluation 370)
Lung, T-4-15 (GO29527/IMpower 010)
A Phase III, Open-Label, Multicenter, Randomized, Study Evaluating the Efficacy and Safety of Atezolizumab (Anti-PD-L1 Antibody) Compared with Best Supportive Care Following Adjuvant Cisplatin-Based Chemotherapy in PD-L1-Selected Patients with Completely Resected Stage IB-IIIA NSCLC
Lung, Alliance A081105
Randomized Double Blind Placebo Controlled Study of Erlotinib or Placebo in Patients with Completely Resected Epidermal Growth Factor Receptor (EGFR) Mutant Non-small Cell Lung Cancer (NSCLC)
Lung, Alliance A151216
Adjuvent Lung Cancer Enrichment Marker Identification and Sequencing
Lung, ECOG E4512
A Phase III Double-Blind Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib versus Placebo for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein
Adjuvant Nivolumab in Resected Lung Cancers (ANVIL) - A Randomized Phase III Study of Nivolumab After Surgical Resection and Adjuvant Chemotherapy in Non-Small Cell Lung Cancers (part of ALCHEMIST study).
Randomized Phase II/III Study of (Nivolumab + Ipilimumab + Sargramostom) vs (Niolumab + Ipilimumab) in Patients with Unresectable Stage III or Stage IV Melanoma
Multiple Myeloma, R-1-17 (C16021) A Phase 3, Randomised , Placebo-Controlled, Double-Blind Study of Oral Ixazomib Maintenance Therapy After Initial Therapy in Patients With Newly Diagnosed Multiple Myeloma Not Treated With Stem Cell Transplantation
Pancreatic, DU-1-17 (AM0010-301, ARTIST 1) A Randomized Phase 3 Study of AM0010 in Combination with FOLFOX Compared with FOLFOX Alone as Second-line Therapy in Patients with Metastatic Pancreatic Cancer that has Progressed During or Following a First-Line Gemcitabine Containing Regimen
Renal, T-1-17 (W039210)
A Phase III, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study Of Atezolizumab (Anti-PD-L1 Antibody) As Adjuvant Therapy in Patients With Renal Cell Carcinoma At High Risk Of Developing Metastasis Following Nephrectomy