Below is a list of current clinical trials open to enrollment at New England Cancer Specialists. Trials can open and close very quickly, depending on the phase of the study, responses from patients already enrolled, or FDA requests.

We try to have a trial available in every disease area, but this isn’t always possible. If you don’t see a study that might be right for you, please ask your doctor or nurse.

For a full list of clinical trials across the U.S., visit www.clinicaltrials.gov.

If you have questions or wish to speak with someone from our research department, contact us

Bladder

Brain

Brain EV-2-16 (OT-15-001) STELLAR
A Phase III, Randomized, Open-Label Study to Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma that Progress/Recur after Irradiation and Adjuvant Temozolomide Chemotherapy. Learn more

 

Breast

Breast, AO11401 (BWEL)
Randomized Phase III Trial Evaluating The Role Of Weight Loss in Adjuvant Treatment Of Overweight And Obese Women With Early Breast Cancer. Learn more

Breast, CB-1-15 (CP-MGAH22-04/SOPHIA)
A Phase III, Randomized Study of Margetuximab Plus Chemotherapy vs. Trastuzumab Plus Chemotherapy in Treatment in Patien
ts with HER2+ MBC Who Have Received Two Prior anti-Her2 Therapies and Require Systemic Treatment. Learn more

Breast, CB-2-15, Alliance Foundation (AFT-05/PALLAS)
Breast, CB-2-15, Alliance Foundation (AFT-05/PALLAS): Palbociclib Collaborative Adjuvant Study: A Randomized Phase III Trial of Palbociclib With Standard Adjuvant Endocrine Therapy Versus Standard Adjuvant Endocrine Therapy Alone for Hormone Receptor Positive (HR+) / Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Early Breast Cancer.  Learn more

Breast, CB-1-17 (MK3475-522) A Phase III, Randomized, Double-blind Study to Evaluate Pembrolizumab plus Chemotherapy vs Placebo plus Chemotherapy as Neoadjuvant Therapy and Pembrolizumab vs Placebo as Adjuvant Therapy for Triple Negative Breast Cancer (TNBC). Learn more

Breast, CB-2-17 (AFT-38/PATINA) A Randomized, Open Label, Phase III Trial to Evaluate the Efficacy and Safety of Palbociclib + Anti-HER2 Therapy + Endocrine Therapy vs. Anti-HER2 Therapy + Endocrine Therapy after Induction Treatment for Hormone Receptor Positive (HR+)/HER2-Positive Metastatic Breast Cancer. Learn more

Breast, CB-3-17 (AFT-25/COMET) Comparison of Operative to Monitoring and Endocrine Therapy (COMET) Trial for Low Risk DCIS: A Phase II Prospective Trial. Learn more

Breast, CB-2-18 (ODO-TE-B301) A Multinational, Multicenter, Randomized, Phase 3 Study of Tesetaxel plus a Reduced Dose of Capecitabine versus Capecitabine Alone in Patients with HER2 Negative, Hormone Receptor Positive, Locally Advanced or Metastatic Breast Cancer Previously Treated with a Taxane. Learn more    Patient Brochure

 

Colorectal

Genomics

Genomics, T-3-17 (JAX2)
A Study of Oncology Clinician And Patient Experiences With Clinical Genomics in Maine. Learn more

Genomics, EAY131 (MATCH)
Molecular Analysis for Therapy Choice. Learn more

Leukemia

Leukemia, R-1-16 (informCLL)
A disease registry for patients with Chronic Lymphocytic Leukemia. Learn more

Lung

Lung, T-4-15 (GO29527/IMpower 010)
A Phase III, Open-Label, Multicenter, Randomized, Study Evaluating the Efficacy and Safety of Atezolizumab (Anti-PD-L1 Antibody) Compared with Best Supportive Care Following Adjuvant Cisplatin-Based Chemotherapy in PD-L1-Selected Patients with Completely Resected Stage IB-IIIA NSCLC. Learn more

Lung, Alliance A081105
Randomized Double Blind Placebo Controlled Study of Erlotinib or Placebo in Patients with Completely Resected Epidermal Growth Factor Receptor (EGFR) Mutant Non-small Cell Lung Cancer (NSCLC). Learn more

Lung, Alliance A151216
Adjuvent Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST). Learn more

Lung, ECOG E4512
A Phase III Double-Blind Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib versus Placebo for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein. Learn more

Lung, EA5142
Adjuvant Nivolumab in Resected Lung Cancers (ANVIL) - A Randomized Phase III Study of Nivolumab After Surgical Resection and Adjuvant Chemotherapy in Non-Small Cell Lung Cancers (part of ALCHEMIST study). Learn more     Patient Brochure

Lung, EV-1-17 (KEYNOTE-598)
A Phase 3, Randomized, Double-Blind Study of Pembrolizumab plus Ipilimumab vs Pembrolizumab plus Placebo in Previously Untreated, Stage IV, Metastatic Non-small Cell Lung Cancer Subjects Whose Tumors are PD-L1 Positive (TPS ≥ 50%). Learn more

Lung, T-1-18 (R2810-ONC-1763)
A Randomized, Open-Label Study of Combinations of Standard and High Dose REGN2810 (Cemiplimab; Anti-PD-1 Antibody) and Ipilimumab (Anti-CTLA-4 Antibody) in the Second-Line Treatment of Patients with Metastatic Non-Small Cell Lung Cancer with Tumors Expressing PD-L1 <50% Learn more

 

Melanoma

Multiple Myeloma

Multiple Myeloma, R-1-17 (C16021) A Phase 3, Randomised , Placebo-Controlled, Double-Blind Study of Oral Ixazomib Maintenance Therapy After Initial Therapy in Patients With Newly Diagnosed Multiple Myeloma Not Treated With Stem Cell Transplantation. Learn more 

Pancreatic

Pancreatic, DU-1-17 (AM0010-301, ARTIST 1) A Randomized Phase 3 Study of AM0010 in Combination with FOLFOX Compared with FOLFOX Alone as Second-line Therapy in Patients with Metastatic Pancreatic Cancer that has Progressed During or Following a First-Line Gemcitabine Containing Regime. Learn more

 

Pancreatic, DU-2-17 (CanStem111p) A Phase III Study of BBI-608 plus nab-Paclitaxel with Gemcitabine in Adult Patients with Metastatic Pancreatic Adenocarcinoma. Learn more

Prostate

Prostate, T-6-17 (AFT-19)
A Study of Androgen Annihilation in High-Risk Biochemically Relapsed Prostate Cancer. Learn more

NECS Providers - For more information on these clinical trials, visit (log-in required): NECS Clinical Trials